Assay Detail
Binding
CHEMBL3381704
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Apparent inhibition of human dCK assessed as phosphorylation activity by spectroscopic NADH-dependent enzyme-coupled assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-guided development of deoxycytidine kinase inhibitors with nanomolar affinity and improved metabolic stability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.31 | 7.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3358091 | — | — | 1 | 7.95 |
| CHEMBL2426574 | — | — | 1 | 7.85 |
| CHEMBL2426570 | — | — | 1 | 7.84 |
| CHEMBL2426573 | — | — | 1 | 7.84 |
| CHEMBL2426565 | — | — | 1 | 7.78 |
| CHEMBL2426567 | — | — | 1 | 7.75 |
| CHEMBL3358094 | — | — | 1 | 7.61 |
| CHEMBL2426568 | — | — | 1 | 7.58 |
| CHEMBL3358097 | — | — | 1 | 7.56 |
| CHEMBL3358096 | — | — | 1 | 7.50 |
| CHEMBL3358093 | — | — | 1 | 7.43 |
| CHEMBL3358090 | — | — | 1 | 6.22 |
| CHEMBL3358092 | — | — | 1 | 6.12 |
| CHEMBL3358095 | — | — | 1 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3358091 | — | IC50 | = | 11.2 | nM | 7.95 |
| CHEMBL2426574 | — | IC50 | = | 14.1 | nM | 7.85 |
| CHEMBL2426570 | — | IC50 | = | 14.6 | nM | 7.84 |
| CHEMBL2426573 | — | IC50 | = | 14.5 | nM | 7.84 |
| CHEMBL2426565 | — | IC50 | = | 16.8 | nM | 7.78 |
| CHEMBL2426567 | — | IC50 | = | 17.9 | nM | 7.75 |
| CHEMBL3358094 | — | IC50 | = | 24.7 | nM | 7.61 |
| CHEMBL2426568 | — | IC50 | = | 26.1 | nM | 7.58 |
| CHEMBL3358097 | — | IC50 | = | 27.8 | nM | 7.56 |
| CHEMBL3358096 | — | IC50 | = | 31.7 | nM | 7.50 |
| CHEMBL3358093 | — | IC50 | = | 37.2 | nM | 7.43 |
| CHEMBL3358090 | — | IC50 | = | 605.0 | nM | 6.22 |
| CHEMBL3358092 | — | IC50 | = | 754.0 | nM | 6.12 |
| CHEMBL3358095 | — | IC50 | = | 5632.0 | nM | 5.25 |