Assay Detail
Binding
CHEMBL3381706
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Inhibition of dCK in human CCRF-CEM cells assessed as inhibition of [3H]-dC uptake by scintillation counting analysis
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-guided development of deoxycytidine kinase inhibitors with nanomolar affinity and improved metabolic stability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.98 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2426567 | — | — | 1 | 9.05 |
| CHEMBL2426570 | — | — | 1 | 8.94 |
| CHEMBL3358096 | — | — | 1 | 8.90 |
| CHEMBL2426573 | — | — | 1 | 8.85 |
| CHEMBL3358097 | — | — | 1 | 8.43 |
| CHEMBL2426574 | — | — | 1 | 8.31 |
| CHEMBL3358094 | — | — | 1 | 8.15 |
| CHEMBL3358093 | — | — | 1 | 8.00 |
| CHEMBL2426565 | — | — | 1 | 7.94 |
| CHEMBL2426568 | — | — | 1 | 7.73 |
| CHEMBL3358091 | — | — | 1 | 7.66 |
| CHEMBL3358090 | — | — | 1 | 7.03 |
| CHEMBL3358092 | — | — | 1 | 6.40 |
| CHEMBL3358095 | — | — | 1 | 6.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2426567 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL2426570 | — | IC50 | = | 1.15 | nM | 8.94 |
| CHEMBL3358096 | — | IC50 | = | 1.25 | nM | 8.90 |
| CHEMBL2426573 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL3358097 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL2426574 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL3358094 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3358093 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2426565 | — | IC50 | = | 11.6 | nM | 7.94 |
| CHEMBL2426568 | — | IC50 | = | 18.6 | nM | 7.73 |
| CHEMBL3358091 | — | IC50 | = | 21.8 | nM | 7.66 |
| CHEMBL3358090 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL3358092 | — | IC50 | = | 395.0 | nM | 6.40 |
| CHEMBL3358095 | — | IC50 | = | 429.5 | nM | 6.37 |