Assay Detail
Binding
CHEMBL3381799
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Influenza A virus H5N1 Neuraminidase H274Y mutant
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of N-substituted oseltamivir derivatives as potent and selective inhibitors of H5N1 influenza neuraminidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.98 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3342483 | — | — | 1 | 6.80 |
| CHEMBL3342456 | — | — | 1 | 6.00 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 5.94 |
| CHEMBL3342459 | — | — | 1 | 5.75 |
| CHEMBL3342478 | — | — | 1 | 5.72 |
| CHEMBL3342485 | — | — | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3342483 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3342456 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL3342459 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL3342478 | — | IC50 | = | 1910.0 | nM | 5.72 |
| CHEMBL3342485 | — | IC50 | = | 2100.0 | nM | 5.68 |