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Assay Detail

CHEMBL3382247

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Binding
Inhibition of DRAK2 (unknown origin) using 33P-ATP after 30 mins by Trilux scintillation counting
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Serine/threonine-protein kinase 17B (CHEMBL3980)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of dual death-associated protein related apoptosis inducing protein kinase 1 and 2 inhibitors by a scaffold hopping approach.
Gao LJ, Kovackova S, Sála M, Ramadori AT, De Jonghe S, Herdewijn P.
J Med Chem (2014) 57 : 7624 -7643
PubMed 25178155 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 5.91 6.07

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3334979 1 6.07
CHEMBL3334980 1 5.75

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3334979 IC50 = 860.0 nM 6.07
CHEMBL3334980 IC50 = 1780.0 nM 5.75