Assay Detail
Functional
CHEMBL3382365
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Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Improved antiproliferative activity of 1,3,4-thiadiazole-containing histone deacetylase (HDAC) inhibitors by introduction of the heteroaromatic surface recognition motif.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.25 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3342182 | — | — | 1 | 5.92 |
| CHEMBL3342179 | — | — | 1 | 5.73 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.64 |
| CHEMBL3342180 | — | — | 1 | 5.33 |
| CHEMBL3342173 | — | — | 1 | 4.93 |
| CHEMBL3342176 | — | — | 1 | 4.82 |
| CHEMBL3342174 | — | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3342182 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL3342179 | — | IC50 | = | 1870.0 | nM | 5.73 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 2290.0 | nM | 5.64 |
| CHEMBL3342180 | — | IC50 | = | 4690.0 | nM | 5.33 |
| CHEMBL3342173 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL3342176 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL3342174 | — | IC50 | = | 40100.0 | nM | 4.40 |