Assay Detail
Binding
CHEMBL3382383
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BCL-2 (unknown origin) incubated for 1 hr by TR-FRET assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 7.12 | 9.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3342193 | — | — | 1 | 9.85 |
| CHEMBL3342197 | — | — | 1 | 7.22 |
| CHEMBL3342332 | A-1155463 | — | 1 | 7.10 |
| CHEMBL3342333 | — | — | 1 | 7.06 |
| CHEMBL3342191 | A-1107969 | — | 1 | 7.05 |
| CHEMBL3342334 | — | — | 1 | 7.05 |
| CHEMBL3342189 | — | — | 1 | 7.00 |
| CHEMBL3342196 | — | — | 1 | 6.85 |
| CHEMBL3342194 | — | — | 1 | 6.82 |
| CHEMBL3342192 | — | — | 1 | 6.77 |
| CHEMBL3342190 | — | — | 1 | 6.66 |
| CHEMBL3342195 | — | — | 1 | 6.62 |
| CHEMBL3342198 | — | — | 1 | 6.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3342193 | — | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL3342197 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL3342332 | A-1155463 | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL3342333 | — | Ki | = | 88.0 | nM | 7.06 |
| CHEMBL3342191 | A-1107969 | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL3342334 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL3342189 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL3342196 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL3342194 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL3342192 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL3342190 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL3342195 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL3342198 | — | Ki | = | 280.0 | nM | 6.55 |