Assay Detail

CHEMBL3382391

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Binding

Binding affinity to BCL-W (unknown origin)

ChEMBL ↗

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Target

Bcl-2-like protein 2 (CHEMBL4677) ↗

Open DB target context

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Bcl-2-like protein 2 (CHEMBL4677) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Bcl-2-like protein 2

CHEMBL4677

Anchored from Assay target.

Protein identity Bcl-2-like protein 2

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Bcl-2-like protein 2 (CHEMBL4677) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.

Tao ZF, Hasvold L, Wang L, Wang X, Petros AM, Park CH, Boghaert ER, Catron ND, Chen J, Colman PM, Czabotar PE, Deshayes K, Fairbrother WJ, Flygare JA, Hymowitz SG, Jin S, Judge RA, Koehler MF, Kovar PJ, Lessene G, Mitten MJ, Ndubaku CO, Nimmer P, Purkey HE, Oleksijew A, Phillips DC, Sleebs BE, Smith BJ, Smith ML, Tahir SK, Watson KG, Xiao Y, Xue J, Zhang H, Zobel K, Rosenberg SH, Tse C, Leverson JD, Elmore SW, Souers AJ.
ACS Med Chem Lett (2014) 5 : 1088 -1093
PubMed 25313317 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	7.72	7.72

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3342332	A-1155463	—	1	7.72

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3342332	A-1155463	Ki	=	19.0	nM	7.72