Assay Detail
Binding
CHEMBL3382784
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Inhibition of human BBOX pre-incubated for 15 mins using TBS-protected fluorescein probe and Fe (II) (Fe(NH4)2(SO4)2 salt by fluoride release assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Ejection of structural zinc leads to inhibition of γ-butyrobetaine hydroxylase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.15 | 6.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51085 | EBSELEN | 3.0 | 1 | 6.12 |
| CHEMBL3335712 | — | — | 1 | 5.50 |
| CHEMBL3335713 | — | — | 1 | 5.47 |
| CHEMBL39469 | BENZENE SELENOIC ACID | — | 1 | 5.20 |
| CHEMBL120563 | THIRAM | 2.0 | 1 | 4.85 |
| CHEMBL3335714 | — | — | 1 | 4.58 |
| CHEMBL3122204 | — | — | 1 | 4.31 |
| CHEMBL426560 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51085 | EBSELEN | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL3335712 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL3335713 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL39469 | BENZENE SELENOIC ACID | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL120563 | THIRAM | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL3335714 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL3122204 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL426560 | — | IC50 | - | — | - |