Assay Detail
Functional
CHEMBL3382999
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Cytotoxicity against human HT-29 cells after 48 hrs by XTT/PMS assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of a new benzophenone-diketopiperazine-type potent antimicrotubule agent possessing a 2-pyridine structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.04 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3342339 | — | — | 1 | 8.15 |
| CHEMBL3342335 | — | — | 1 | 7.82 |
| CHEMBL3342342 | — | — | 1 | 7.12 |
| CHEMBL3342338 | — | — | 1 | 7.03 |
| CHEMBL3342336 | — | — | 1 | 5.06 |
| CHEMBL3342337 | — | — | 1 | - |
| CHEMBL3342340 | — | — | 1 | - |
| CHEMBL3342341 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3342339 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3342335 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3342342 | — | IC50 | = | 75.3 | nM | 7.12 |
| CHEMBL3342338 | — | IC50 | = | 94.3 | nM | 7.03 |
| CHEMBL3342336 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL3342337 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3342340 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3342341 | — | IC50 | > | 1000.0 | nM | - |