Assay Detail

CHEMBL3383002

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Functional

Cytotoxicity against human HeLa cells after 48 hrs by WST8 assay

ChEMBL ↗

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Target

HeLa (CHEMBL399) ↗

Open DB target context

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Primary target HeLa

CHEMBL399

Anchored from Assay target.

Protein identity HeLa

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	HeLa
Confidence	1 — Organism
Curated By	Autocuration

Target

HeLa (CHEMBL399) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Development of a new benzophenone-diketopiperazine-type potent antimicrotubule agent possessing a 2-pyridine structure.

Hayashi Y, Takeno H, Chinen T, Muguruma K, Okuyama K, Taguchi A, Takayama K, Yakushiji F, Miura M, Usui T, Hayashi Y.
ACS Med Chem Lett (2014) 5 : 1094 -1098
PubMed 25313318 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	7.98	8.27

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3342339	—	—	1	8.27
CHEMBL1096380	PLINABULIN	3.0	1	7.69

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3342339	—	IC50	=	5.4	nM	8.27
CHEMBL1096380	PLINABULIN	IC50	=	20.6	nM	7.69