Assay Detail
Binding
CHEMBL3383054
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Inhibition of electric eel AChE by Ellman's method
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Active compounds from a diverse library of triazolothiadiazole and triazolothiadiazine scaffolds: synthesis, crystal structure determination, cytotoxicity, cholinesterase inhibitory activity, and binding mode analysis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 4.74 | 5.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3338952 | — | — | 1 | 5.51 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 5.14 |
| CHEMBL3338954 | — | — | 1 | 4.95 |
| CHEMBL3338949 | — | — | 1 | 4.86 |
| CHEMBL3338957 | — | — | 1 | 4.82 |
| CHEMBL3338962 | — | — | 1 | 4.74 |
| CHEMBL1588892 | — | — | 1 | 4.67 |
| CHEMBL278020 | NEOSTIGMINE | 4.0 | 1 | 4.55 |
| CHEMBL3338951 | — | — | 1 | 4.45 |
| CHEMBL3338963 | — | — | 1 | 4.42 |
| CHEMBL3338947 | — | — | 1 | 4.42 |
| CHEMBL3338960 | — | — | 1 | 4.40 |
| CHEMBL3338956 | — | — | 1 | - |
| CHEMBL3338953 | — | — | 1 | - |
| CHEMBL3338946 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3338952 | — | IC50 | = | 3090.0 | nM | 5.51 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 7230.0 | nM | 5.14 |
| CHEMBL3338954 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL3338949 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL3338957 | — | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL3338962 | — | IC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL1588892 | — | IC50 | = | 21200.0 | nM | 4.67 |
| CHEMBL278020 | NEOSTIGMINE | IC50 | = | 28300.0 | nM | 4.55 |
| CHEMBL3338951 | — | IC50 | = | 35500.0 | nM | 4.45 |
| CHEMBL3338963 | — | IC50 | = | 38500.0 | nM | 4.42 |
| CHEMBL3338947 | — | IC50 | = | 37700.0 | nM | 4.42 |
| CHEMBL3338960 | — | IC50 | = | 39700.0 | nM | 4.40 |
| CHEMBL3338956 | — | IC50 | - | — | - | |
| CHEMBL3338953 | — | IC50 | - | — | - | |
| CHEMBL3338946 | — | IC50 | - | — | - |