Assay Detail
Binding
CHEMBL3383058
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]CP-55,940 from human recombinant CB1R expressed in HEK-293 cells after 90 mins by liquid scintillation counting
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
CB2-selective cannabinoid receptor ligands: synthesis, pharmacological evaluation, and molecular modeling investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 36 | 6.42 | 7.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3353437 | — | — | 1 | 7.65 |
| CHEMBL3353452 | — | — | 1 | 7.49 |
| CHEMBL3353438 | — | — | 1 | 7.45 |
| CHEMBL3353454 | — | — | 1 | 7.28 |
| CHEMBL3353453 | — | — | 1 | 7.18 |
| CHEMBL3353439 | — | — | 1 | 7.02 |
| CHEMBL3353441 | — | — | 1 | 6.92 |
| CHEMBL3353440 | — | — | 1 | 6.78 |
| CHEMBL466651 | — | — | 1 | 6.70 |
| CHEMBL3353445 | — | — | 1 | 6.37 |
| CHEMBL381689 | SR-144528 | — | 1 | 6.36 |
| CHEMBL3353446 | — | — | 1 | 6.33 |
| CHEMBL371214 | — | — | 1 | 6.17 |
| CHEMBL3353442 | — | — | 1 | 6.12 |
| CHEMBL3353424 | — | — | 1 | 6.04 |
| CHEMBL466223 | — | — | 1 | 6.00 |
| CHEMBL3353436 | — | — | 1 | 6.00 |
| CHEMBL3353423 | — | — | 1 | 5.64 |
| CHEMBL3353443 | — | — | 1 | 5.49 |
| CHEMBL3353444 | — | — | 1 | 5.48 |
| CHEMBL3353448 | — | — | 1 | 5.46 |
| CHEMBL3353450 | — | — | 1 | 5.39 |
| CHEMBL3353449 | — | — | 1 | - |
| CHEMBL3353425 | — | — | 1 | - |
| CHEMBL3353426 | — | — | 1 | - |
| CHEMBL3353427 | — | — | 1 | - |
| CHEMBL3353428 | — | — | 1 | - |
| CHEMBL3353429 | — | — | 1 | - |
| CHEMBL3353430 | — | — | 1 | - |
| CHEMBL3353431 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3353437 | — | Ki | = | 22.59 | nM | 7.65 |
| CHEMBL3353452 | — | Ki | = | 32.7 | nM | 7.49 |
| CHEMBL3353438 | — | Ki | = | 35.67 | nM | 7.45 |
| CHEMBL3353454 | — | Ki | = | 52.9 | nM | 7.28 |
| CHEMBL3353453 | — | Ki | = | 66.7 | nM | 7.18 |
| CHEMBL3353439 | — | Ki | = | 96.1 | nM | 7.02 |
| CHEMBL3353441 | — | Ki | = | 121.0 | nM | 6.92 |
| CHEMBL3353440 | — | Ki | = | 166.0 | nM | 6.78 |
| CHEMBL466651 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL3353445 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL381689 | SR-144528 | Ki | = | 437.0 | nM | 6.36 |
| CHEMBL3353446 | — | Ki | = | 472.0 | nM | 6.33 |
| CHEMBL371214 | — | Ki | = | 677.0 | nM | 6.17 |
| CHEMBL3353442 | — | Ki | = | 750.0 | nM | 6.12 |
| CHEMBL3353424 | — | Ki | = | 908.0 | nM | 6.04 |
| CHEMBL466223 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL3353436 | — | Ki | = | 1011.0 | nM | 6.00 |
| CHEMBL3353423 | — | Ki | = | 2314.0 | nM | 5.64 |
| CHEMBL3353443 | — | Ki | = | 3262.0 | nM | 5.49 |
| CHEMBL3353444 | — | Ki | = | 3280.0 | nM | 5.48 |
| CHEMBL3353448 | — | Ki | = | 3444.0 | nM | 5.46 |
| CHEMBL3353450 | — | Ki | = | 4056.0 | nM | 5.39 |
| CHEMBL3353447 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3353451 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3353435 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3353434 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3353433 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3353432 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3353431 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3353430 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3353429 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3353428 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3353427 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3353426 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3353425 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3353449 | — | Ki | > | 10000.0 | nM | - |