Assay Detail
Binding
CHEMBL3383111
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Inhibition of human dopamine D3 receptor
16
Total Activities
9
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and Characterization of ML398, a Potent and Selective Antagonist of the D4 Receptor with in Vivo Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.23 | 5.56 |
| IC50 | 7 | 4.76 | 5.09 |
| INH | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3335538 | — | — | 2 | 5.56 |
| CHEMBL3335539 | — | — | 2 | 5.56 |
| CHEMBL3335554 | — | — | 2 | 5.56 |
| CHEMBL3335555 | — | — | 2 | 5.56 |
| CHEMBL3335535 | — | — | 2 | 4.97 |
| CHEMBL3335537 | — | — | 2 | 4.80 |
| CHEMBL3335536 | — | — | 2 | 4.59 |
| CHEMBL3335556 | — | — | 1 | - |
| CHEMBL3335540 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3335538 | — | Ki | = | 2770.0 | nM | 5.56 |
| CHEMBL3335539 | — | Ki | = | 2770.0 | nM | 5.56 |
| CHEMBL3335554 | — | Ki | = | 2770.0 | nM | 5.56 |
| CHEMBL3335555 | — | Ki | = | 2770.0 | nM | 5.56 |
| CHEMBL3335538 | — | IC50 | = | 8170.0 | nM | 5.09 |
| CHEMBL3335539 | — | IC50 | = | 8170.0 | nM | 5.09 |
| CHEMBL3335554 | — | IC50 | = | 8170.0 | nM | 5.09 |
| CHEMBL3335555 | — | IC50 | = | 8170.0 | nM | 5.09 |
| CHEMBL3335535 | — | Ki | = | 10800.0 | nM | 4.97 |
| CHEMBL3335537 | — | Ki | = | 15700.0 | nM | 4.80 |
| CHEMBL3335536 | — | Ki | = | 25900.0 | nM | 4.59 |
| CHEMBL3335535 | — | IC50 | = | 31800.0 | nM | 4.50 |
| CHEMBL3335537 | — | IC50 | = | 46200.0 | nM | 4.33 |
| CHEMBL3335536 | — | IC50 | = | 76400.0 | nM | 4.12 |
| CHEMBL3335556 | — | INH | > | 20.0 | uM | - |
| CHEMBL3335540 | — | INH | > | 20.0 | uM | - |