Assay Detail
Binding
CHEMBL3383444
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Binding affinity to human BBOX in presence of Fe(II) by tryptophan fluorescence quenching binding assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Ejection of structural zinc leads to inhibition of γ-butyrobetaine hydroxylase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 4.95 | 5.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51085 | EBSELEN | 3.0 | 1 | 5.34 |
| CHEMBL3335712 | — | — | 1 | 5.12 |
| CHEMBL3335713 | — | — | 1 | 4.96 |
| CHEMBL39469 | BENZENE SELENOIC ACID | — | 1 | 4.92 |
| CHEMBL426560 | — | — | 1 | 4.89 |
| CHEMBL120563 | THIRAM | 2.0 | 1 | 4.46 |
| CHEMBL3335714 | — | — | 1 | - |
| CHEMBL3122204 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51085 | EBSELEN | Kd | = | 4600.0 | nM | 5.34 |
| CHEMBL3335712 | — | Kd | = | 7500.0 | nM | 5.12 |
| CHEMBL3335713 | — | Kd | = | 11000.0 | nM | 4.96 |
| CHEMBL39469 | BENZENE SELENOIC ACID | Kd | = | 12000.0 | nM | 4.92 |
| CHEMBL426560 | — | Kd | = | 13000.0 | nM | 4.89 |
| CHEMBL120563 | THIRAM | Kd | = | 35000.0 | nM | 4.46 |
| CHEMBL3335714 | — | Kd | > | 200000.0 | nM | - |
| CHEMBL3122204 | — | Kd | > | 200000.0 | nM | - |