Assay Detail
Binding
CHEMBL3383761
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDE9A2 catalytic domain (unknown origin) using [3H]-cGMP/[3H]-cAMP as substrate after 15 mins by liquid scintillation counting analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (CHEMBL3535) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a phosphodiesterase 9A inhibitor as a potential hypoglycemic agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.28 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3360415 | — | — | 1 | 9.22 |
| CHEMBL3360419 | — | — | 1 | 8.98 |
| CHEMBL3360421 | — | — | 1 | 8.96 |
| CHEMBL3360416 | — | — | 1 | 8.52 |
| CHEMBL3360414 | — | — | 1 | 8.26 |
| CHEMBL3360412 | — | — | 1 | 8.19 |
| CHEMBL3360417 | — | — | 1 | 8.09 |
| CHEMBL3360420 | — | — | 1 | 7.75 |
| CHEMBL3360418 | — | — | 1 | 7.59 |
| CHEMBL3360411 | — | — | 1 | 7.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3360415 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL3360419 | — | IC50 | = | 1.05 | nM | 8.98 |
| CHEMBL3360421 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL3360416 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3360414 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL3360412 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL3360417 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL3360420 | — | IC50 | = | 17.6 | nM | 7.75 |
| CHEMBL3360418 | — | IC50 | = | 25.9 | nM | 7.59 |
| CHEMBL3360411 | — | IC50 | = | 52.0 | nM | 7.28 |