Assay Detail
Binding
CHEMBL3383767
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDE10A2 catalytic domain (unknown origin) using [3H]-cGMP/[3H]-cAMP as substrate after 15 mins by liquid scintillation counting analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (CHEMBL4409) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a phosphodiesterase 9A inhibitor as a potential hypoglycemic agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.02 | 5.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3360412 | — | — | 1 | 5.43 |
| CHEMBL3360415 | — | — | 1 | 5.16 |
| CHEMBL3360416 | — | — | 1 | 4.48 |
| CHEMBL3360413 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3360412 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL3360415 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL3360416 | — | IC50 | = | 33300.0 | nM | 4.48 |
| CHEMBL3360413 | — | IC50 | > | 50000.0 | nM | - |