Assay Detail
Binding
CHEMBL3384004
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Inhibition of dengue virus NS2B-NS3 protease
11
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Dengue virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
A perspective on targeting non-structural proteins to combat neglected tropical diseases: Dengue, West Nile and Chikungunya viruses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.93 | 5.43 |
| Ki | 3 | 5.39 | 5.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3344306 | — | — | 2 | 5.47 |
| CHEMBL2312794 | — | — | 1 | 5.43 |
| CHEMBL3344304 | — | — | 2 | 5.40 |
| CHEMBL3344305 | — | — | 2 | 5.31 |
| CHEMBL1255949 | — | — | 1 | 4.93 |
| CHEMBL539922 | — | — | 1 | 4.85 |
| CHEMBL3352908 | — | — | 1 | 4.16 |
| CHEMBL3352909 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3344306 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL2312794 | — | IC50 | = | 3750.0 | nM | 5.43 |
| CHEMBL3344306 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL3344304 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL3344305 | — | Ki | = | 4900.0 | nM | 5.31 |
| CHEMBL1255949 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL3344305 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL539922 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL3344304 | — | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL3352908 | — | IC50 | = | 69000.0 | nM | 4.16 |
| CHEMBL3352909 | — | IC50 | = | 121000.0 | nM | - |