Assay Detail
Binding
CHEMBL3384009
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Inhibition of dengue virus-2 NS2B-NS3 protease
6
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | dengue virus type 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A perspective on targeting non-structural proteins to combat neglected tropical diseases: Dengue, West Nile and Chikungunya viruses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.18 | 6.00 |
| Ki | 3 | 5.18 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL205548 | — | — | 1 | 6.00 |
| CHEMBL3344303 | — | — | 2 | 5.70 |
| CHEMBL3344310 | — | — | 1 | 5.32 |
| CHEMBL1181020 | — | — | 2 | 4.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL205548 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3344303 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL3344310 | — | Ki | = | 4800.0 | nM | 5.32 |
| CHEMBL3344303 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL1181020 | — | Ki | = | 31100.0 | nM | 4.51 |
| CHEMBL1181020 | — | IC50 | = | 37900.0 | nM | 4.42 |