Assay Detail
Functional
CHEMBL3384077
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Cytotoxicity against human MDA-MB-231 cells after 72 hrs by sulforhodamine B assay
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of 2-phenylnaphthalenoids as inhibitors of DNA topoisomeraseIIα and antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 49 | 4.92 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3330517 | — | — | 1 | 6.40 |
| CHEMBL3330540 | — | — | 1 | 6.30 |
| CHEMBL3330523 | — | — | 1 | 6.30 |
| CHEMBL3329421 | — | — | 1 | 6.00 |
| CHEMBL3330543 | — | — | 1 | 5.85 |
| CHEMBL3330545 | — | — | 1 | 5.68 |
| CHEMBL3329417 | — | — | 1 | 5.62 |
| CHEMBL3330519 | — | — | 1 | 5.50 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.43 |
| CHEMBL3329222 | — | — | 1 | 5.37 |
| CHEMBL3330525 | — | — | 1 | 5.35 |
| CHEMBL407112 | — | — | 1 | 5.30 |
| CHEMBL3330533 | — | — | 1 | 5.12 |
| CHEMBL3330521 | — | — | 1 | 5.12 |
| CHEMBL3329419 | — | — | 1 | 5.09 |
| CHEMBL191974 | — | — | 1 | 4.98 |
| CHEMBL3329416 | — | — | 1 | 4.78 |
| CHEMBL3330528 | — | — | 1 | 4.74 |
| CHEMBL3330544 | — | — | 1 | 4.70 |
| CHEMBL3330538 | — | — | 1 | 4.70 |
| CHEMBL3330537 | — | — | 1 | 4.62 |
| CHEMBL3330520 | — | — | 1 | 4.60 |
| CHEMBL261428 | — | — | 1 | 4.53 |
| CHEMBL3329423 | — | — | 1 | 4.50 |
| CHEMBL3330522 | — | — | 1 | 4.44 |
| CHEMBL3330532 | — | — | 1 | 4.26 |
| CHEMBL3330524 | — | — | 1 | 4.21 |
| CHEMBL3330534 | — | — | 1 | 4.16 |
| CHEMBL3329420 | — | — | 1 | 4.11 |
| CHEMBL3329422 | — | — | 1 | 4.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3330517 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3330540 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3330523 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3329421 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3330543 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3330545 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3329417 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL3330519 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 3670.0 | nM | 5.43 |
| CHEMBL3329222 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL3330525 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL407112 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3330521 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL3330533 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL3329419 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL191974 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL3329416 | — | IC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL3330528 | — | IC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL3330544 | — | IC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL3330538 | — | IC50 | = | 19900.0 | nM | 4.70 |
| CHEMBL3330537 | — | IC50 | = | 24200.0 | nM | 4.62 |
| CHEMBL3330520 | — | IC50 | = | 25300.0 | nM | 4.60 |
| CHEMBL261428 | — | IC50 | = | 29500.0 | nM | 4.53 |
| CHEMBL3329423 | — | IC50 | = | 31500.0 | nM | 4.50 |
| CHEMBL3330522 | — | IC50 | = | 36500.0 | nM | 4.44 |
| CHEMBL3330532 | — | IC50 | = | 54900.0 | nM | 4.26 |
| CHEMBL3330524 | — | IC50 | = | 61800.0 | nM | 4.21 |
| CHEMBL3330534 | — | IC50 | = | 69800.0 | nM | 4.16 |
| CHEMBL3329420 | — | IC50 | = | 77300.0 | nM | 4.11 |
| CHEMBL3329422 | — | IC50 | = | 81800.0 | nM | 4.09 |
| CHEMBL3330512 | — | IC50 | = | 82200.0 | nM | 4.08 |
| CHEMBL3330518 | — | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL3330542 | — | IC50 | = | 94300.0 | nM | 4.03 |
| CHEMBL3330513 | — | IC50 | = | 93300.0 | nM | 4.03 |
| CHEMBL3330514 | — | IC50 | = | 98000.0 | nM | 4.01 |
| CHEMBL3329415 | — | IC50 | = | 112500.0 | nM | - |
| CHEMBL3329418 | — | IC50 | > | 800000.0 | nM | - |
| CHEMBL3330515 | — | IC50 | > | 800000.0 | nM | - |
| CHEMBL3330516 | — | IC50 | > | 800000.0 | nM | - |
| CHEMBL3330527 | — | IC50 | > | 800000.0 | nM | - |
| CHEMBL3330529 | — | IC50 | = | 168000.0 | nM | - |
| CHEMBL3330530 | — | IC50 | = | 152000.0 | nM | - |
| CHEMBL3330531 | — | IC50 | > | 800000.0 | nM | - |
| CHEMBL3330535 | — | IC50 | = | 695000.0 | nM | - |
| CHEMBL3330536 | — | IC50 | = | 272000.0 | nM | - |
| CHEMBL3330526 | — | IC50 | = | 165000.0 | nM | - |
| CHEMBL3330546 | — | IC50 | > | 800000.0 | nM | - |
| CHEMBL3330539 | — | IC50 | = | 455000.0 | nM | - |
| CHEMBL3330541 | — | IC50 | > | 800000.0 | nM | - |