Assay Detail
Functional
CHEMBL3384078
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Cytotoxicity against human A549 cells after 72 hrs by sulforhodamine B assay
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of 2-phenylnaphthalenoids as inhibitors of DNA topoisomeraseIIα and antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 48 | 5.16 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3330517 | — | — | 1 | 6.22 |
| CHEMBL3330523 | — | — | 1 | 5.96 |
| CHEMBL3329421 | — | — | 1 | 5.55 |
| CHEMBL3330545 | — | — | 1 | 5.46 |
| CHEMBL3330525 | — | — | 1 | 5.46 |
| CHEMBL3330543 | — | — | 1 | 5.38 |
| CHEMBL3329417 | — | — | 1 | 5.30 |
| CHEMBL3330540 | — | — | 1 | 5.30 |
| CHEMBL3330530 | — | — | 1 | 5.10 |
| CHEMBL407112 | — | — | 1 | 5.04 |
| CHEMBL3330519 | — | — | 1 | 4.98 |
| CHEMBL3329222 | — | — | 1 | 4.94 |
| CHEMBL191974 | — | — | 1 | 4.94 |
| CHEMBL3330521 | — | — | 1 | 4.94 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 4.86 |
| CHEMBL3330520 | — | — | 1 | 4.85 |
| CHEMBL3329419 | — | — | 1 | 4.82 |
| CHEMBL3330533 | — | — | 1 | 4.70 |
| CHEMBL3330528 | — | — | 1 | 4.70 |
| CHEMBL3329416 | — | — | 1 | 4.70 |
| CHEMBL3330544 | — | — | 1 | - |
| CHEMBL3329418 | — | — | 1 | - |
| CHEMBL3330542 | — | — | 1 | - |
| CHEMBL3330541 | — | — | 1 | - |
| CHEMBL3330546 | — | — | 1 | - |
| CHEMBL3330539 | — | — | 1 | - |
| CHEMBL3329415 | — | — | 1 | - |
| CHEMBL3330538 | — | — | 1 | - |
| CHEMBL3329420 | — | — | 1 | - |
| CHEMBL3330537 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3330517 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3330523 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3329421 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL3330545 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL3330525 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL3330543 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL3329417 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3330540 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3330530 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL407112 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL3330519 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL3329222 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL191974 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL3330521 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 13780.0 | nM | 4.86 |
| CHEMBL3330520 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL3329419 | — | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL3330533 | — | IC50 | = | 19900.0 | nM | 4.70 |
| CHEMBL3329416 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL3330528 | — | IC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL3330516 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3330515 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3330522 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3330513 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3330524 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3330512 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3330526 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3329423 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3330527 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3330529 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL261428 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3329422 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3330531 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3330518 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3330534 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3330532 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3330535 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3330536 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3330537 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3329420 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3330538 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3329415 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3330539 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3330546 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3330541 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3330542 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3329418 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3330544 | — | IC50 | > | 20000.0 | nM | - |