Assay Detail
Functional
CHEMBL3384273
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Antimalarial activity against Plasmodium falciparum 3D7 assessed as parasite growth inhibition after 72 hrs by DAPI staining based confocal microscopy
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Two-pronged attack: dual inhibition of Plasmodium falciparum M1 and M17 metalloaminopeptidases by a novel series of hydroxamic acid-based inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.37 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3359693 | — | — | 1 | 6.64 |
| CHEMBL3359700 | — | — | 1 | 6.64 |
| CHEMBL3359699 | — | — | 1 | 6.63 |
| CHEMBL3359696 | — | — | 1 | 6.46 |
| CHEMBL3359697 | — | — | 1 | 6.37 |
| CHEMBL3359691 | — | — | 1 | 6.34 |
| CHEMBL3359692 | — | — | 1 | 6.27 |
| CHEMBL3359694 | — | — | 1 | 6.22 |
| CHEMBL3359690 | — | — | 1 | 6.21 |
| CHEMBL3359698 | — | — | 1 | 6.15 |
| CHEMBL3359688 | — | — | 1 | 6.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3359693 | — | IC50 | = | 227.0 | nM | 6.64 |
| CHEMBL3359700 | — | IC50 | = | 228.0 | nM | 6.64 |
| CHEMBL3359699 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL3359696 | — | IC50 | = | 351.0 | nM | 6.46 |
| CHEMBL3359697 | — | IC50 | = | 429.0 | nM | 6.37 |
| CHEMBL3359691 | — | IC50 | = | 455.0 | nM | 6.34 |
| CHEMBL3359692 | — | IC50 | = | 532.0 | nM | 6.27 |
| CHEMBL3359694 | — | IC50 | = | 597.0 | nM | 6.22 |
| CHEMBL3359690 | — | IC50 | = | 619.0 | nM | 6.21 |
| CHEMBL3359698 | — | IC50 | = | 703.0 | nM | 6.15 |
| CHEMBL3359688 | — | IC50 | = | 783.0 | nM | 6.11 |