Assay Detail
Binding
CHEMBL3384692
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Inhibition of intestinal sucrase (unknown origin)
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification and development of biphenyl substituted iminosugars as improved dual glucosylceramide synthase/neutral glucosylceramidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.79 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3354063 | — | — | 1 | 6.70 |
| CHEMBL3354062 | — | — | 1 | 6.70 |
| CHEMBL3354025 | — | — | 1 | 6.60 |
| CHEMBL3354624 | — | — | 1 | 6.60 |
| CHEMBL3354622 | — | — | 1 | 6.60 |
| CHEMBL3354625 | — | — | 1 | 6.40 |
| CHEMBL3354621 | — | — | 1 | 6.40 |
| CHEMBL3354623 | — | — | 1 | 6.30 |
| CHEMBL574645 | — | — | 1 | 6.22 |
| CHEMBL3354627 | — | — | 1 | 5.90 |
| CHEMBL3354626 | — | — | 1 | 5.82 |
| CHEMBL3354620 | — | — | 1 | 4.46 |
| CHEMBL3354038 | — | — | 1 | 4.16 |
| CHEMBL3354630 | — | — | 1 | 4.02 |
| CHEMBL3354631 | — | — | 1 | 4.00 |
| CHEMBL3354637 | NIZUBAGLUSTAT | 2.0 | 1 | - |
| CHEMBL3354636 | — | — | 1 | - |
| CHEMBL3354635 | — | — | 1 | - |
| CHEMBL3354634 | — | — | 1 | - |
| CHEMBL3354633 | — | — | 1 | - |
| CHEMBL3354632 | — | — | 1 | - |
| CHEMBL3354629 | — | — | 1 | - |
| CHEMBL3354628 | — | — | 1 | - |
| CHEMBL1086996 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3354063 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3354062 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3354025 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL3354624 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL3354622 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL3354625 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3354621 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3354623 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL574645 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3354627 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL3354626 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3354620 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL3354038 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL3354630 | — | IC50 | = | 95000.0 | nM | 4.02 |
| CHEMBL3354631 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL3354637 | NIZUBAGLUSTAT | IC50 | > | 100000.0 | nM | - |
| CHEMBL3354636 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3354635 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3354634 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3354633 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3354632 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3354629 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3354628 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1086996 | — | IC50 | > | 100000.0 | nM | - |