Assay Detail
Binding
CHEMBL3384714
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BRAF (unknown origin)-mediated ERK phosphorylation by cell-based assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase B-raf (CHEMBL5145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and Synthesis of Orally Bioavailable Benzimidazole Reverse Amides as Pan RAF Kinase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 7.05 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3335371 | — | — | 1 | 7.40 |
| CHEMBL3335380 | — | — | 1 | 7.30 |
| CHEMBL3335376 | — | — | 1 | 7.30 |
| CHEMBL3335373 | — | — | 1 | 7.30 |
| CHEMBL3335377 | — | — | 1 | 7.10 |
| CHEMBL3335378 | — | — | 1 | 7.05 |
| CHEMBL3335381 | — | — | 1 | 7.05 |
| CHEMBL3335372 | — | — | 1 | 7.00 |
| CHEMBL3335383 | — | — | 1 | 7.00 |
| CHEMBL3335374 | — | — | 1 | 7.00 |
| CHEMBL3335385 | — | — | 1 | 7.00 |
| CHEMBL3335382 | — | — | 1 | 7.00 |
| CHEMBL3335386 | — | — | 1 | 7.00 |
| CHEMBL3335387 | — | — | 1 | 7.00 |
| CHEMBL3335384 | — | — | 1 | 7.00 |
| CHEMBL3335379 | — | — | 1 | 7.00 |
| CHEMBL3335375 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3335371 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3335380 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3335376 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3335373 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3335377 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3335378 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3335381 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3335372 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3335383 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3335374 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3335385 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3335382 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3335386 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3335387 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3335384 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3335379 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3335375 | — | EC50 | = | 400.0 | nM | 6.40 |