Assay Detail
Functional
CHEMBL3384816
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Antiviral activity against HCV genotype 1b infected in human Huh-7 cells by firefly luciferase assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.12 | 5.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3356720 | — | — | 1 | 5.27 |
| CHEMBL3356721 | — | — | 1 | 5.27 |
| CHEMBL3356714 | — | — | 1 | 4.82 |
| CHEMBL3125046 | — | — | 1 | - |
| CHEMBL3125047 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3356720 | — | EC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL3356721 | — | EC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL3356714 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3125046 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3125047 | — | EC50 | > | 10000.0 | nM | - |