Assay Detail

CHEMBL3384818

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Antiviral activity against HCV genotype 1b

ChEMBL ↗

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Target

Hepatitis C virus (CHEMBL379) ↗

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Primary target Hepatitis C virus

CHEMBL379

Anchored from Assay target.

Protein identity Hepatitis C virus

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Hepacivirus hominis
Confidence	1 — Organism
Curated By	Autocuration

Target

Hepatitis C virus (CHEMBL379) ↗

Type	ORGANISM
Organism	Hepacivirus hominis

Publication

Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles.

Lampa A, Alogheli H, Ehrenberg AE, Åkerblom E, Svensson R, Artursson P, Danielson UH, Karlén A, Sandström A.
Bioorg Med Chem (2014) 22 : 6595 -6615
PubMed 25456385 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	8.51	8.51

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1241348	FALDAPREVIR	3.0	1	8.51

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1241348	FALDAPREVIR	EC50	=	3.1	nM	8.51