Assay Detail
Functional
CHEMBL3384902
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Agonist activity at human GPR39 by IP1 assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 2-Pyridylpyrimidines as the First Orally Bioavailable GPR39 Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.92 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3342358 | — | — | 1 | 9.10 |
| CHEMBL3341764 | — | — | 1 | 7.96 |
| CHEMBL3342357 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3342358 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL3341764 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3342357 | — | EC50 | = | 202.0 | nM | 6.70 |