Assay Detail
Functional
CHEMBL3384910
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human NCI-H157 cells by sulforhodamine B assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H157 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Active compounds from a diverse library of triazolothiadiazole and triazolothiadiazine scaffolds: synthesis, crystal structure determination, cytotoxicity, cholinesterase inhibitory activity, and binding mode analysis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.61 | 6.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3338963 | — | — | 1 | 6.02 |
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 5.99 |
| CHEMBL3338945 | — | — | 1 | 5.97 |
| CHEMBL3338962 | — | — | 1 | 5.85 |
| CHEMBL1466313 | — | — | 1 | 5.78 |
| CHEMBL3338948 | — | — | 1 | 5.78 |
| CHEMBL3338958 | — | — | 1 | 5.73 |
| CHEMBL3338944 | — | — | 1 | 5.73 |
| CHEMBL3338955 | — | — | 1 | 5.71 |
| CHEMBL3338956 | — | — | 1 | 5.71 |
| CHEMBL3338950 | — | — | 1 | 5.54 |
| CHEMBL3338947 | — | — | 1 | 5.53 |
| CHEMBL3338954 | — | — | 1 | 5.53 |
| CHEMBL3338952 | — | — | 1 | 5.52 |
| CHEMBL1588892 | — | — | 1 | 5.50 |
| CHEMBL3338953 | — | — | 1 | 5.48 |
| CHEMBL3338946 | — | — | 1 | 5.47 |
| CHEMBL3338951 | — | — | 1 | 5.43 |
| CHEMBL3338957 | — | — | 1 | 5.41 |
| CHEMBL3338959 | — | — | 1 | 5.41 |
| CHEMBL3338960 | — | — | 1 | 5.37 |
| CHEMBL3338949 | — | — | 1 | 5.29 |
| CHEMBL3338961 | — | — | 1 | 5.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3338963 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL90555 | VINCRISTINE | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL3338945 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL3338962 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL1466313 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL3338948 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL3338958 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL3338944 | — | IC50 | = | 1870.0 | nM | 5.73 |
| CHEMBL3338955 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL3338956 | — | IC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL3338950 | — | IC50 | = | 2920.0 | nM | 5.54 |
| CHEMBL3338947 | — | IC50 | = | 2930.0 | nM | 5.53 |
| CHEMBL3338954 | — | IC50 | = | 2980.0 | nM | 5.53 |
| CHEMBL3338952 | — | IC50 | = | 3010.0 | nM | 5.52 |
| CHEMBL1588892 | — | IC50 | = | 3160.0 | nM | 5.50 |
| CHEMBL3338953 | — | IC50 | = | 3290.0 | nM | 5.48 |
| CHEMBL3338946 | — | IC50 | = | 3410.0 | nM | 5.47 |
| CHEMBL3338951 | — | IC50 | = | 3670.0 | nM | 5.43 |
| CHEMBL3338957 | — | IC50 | = | 3940.0 | nM | 5.41 |
| CHEMBL3338959 | — | IC50 | = | 3870.0 | nM | 5.41 |
| CHEMBL3338960 | — | IC50 | = | 4320.0 | nM | 5.37 |
| CHEMBL3338949 | — | IC50 | = | 5140.0 | nM | 5.29 |
| CHEMBL3338961 | — | IC50 | = | 5370.0 | nM | 5.27 |