Assay Detail
Binding
CHEMBL3385303
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inverse agonist activity at RORgammaT (unknown origin) by Jurkat cell based luciferase assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for RORβ and RORγt.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.45 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3105681 | — | — | 1 | 8.00 |
| CHEMBL3105674 | — | — | 1 | 6.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3105681 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3105674 | — | IC50 | = | 125.89 | nM | 6.90 |