Assay Detail
Binding
CHEMBL3385309
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Inverse agonist activity at RORgammaT (unknown origin) by M1H assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for RORβ and RORγt.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.23 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3105681 | — | — | 1 | 8.10 |
| CHEMBL3105674 | — | — | 1 | 7.80 |
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 6.70 |
| CHEMBL62136 | T091317 | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3105681 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL3105674 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL38 | TRETINOIN | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL62136 | T091317 | IC50 | = | 501.19 | nM | 6.30 |