Assay Detail
Binding
CHEMBL3385423
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant FLT3 D835Y mutant (unknown origin) by TR-FRET assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-type tyrosine-protein kinase FLT3 (CHEMBL1974) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and biological evaluation of FLT3 covalent inhibitors with a resorcylic acid core.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.59 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2012519 | — | — | 1 | 7.96 |
| CHEMBL3357191 | — | — | 1 | 6.09 |
| CHEMBL3357190 | — | — | 1 | 6.03 |
| CHEMBL3357193 | — | — | 1 | 6.02 |
| CHEMBL3357188 | — | — | 1 | 5.87 |
| CHEMBL3357192 | — | — | 1 | 5.76 |
| CHEMBL3357194 | — | — | 1 | 5.68 |
| CHEMBL3357177 | — | — | 1 | 5.55 |
| CHEMBL3357189 | — | — | 1 | 5.52 |
| CHEMBL3357187 | — | — | 1 | 5.44 |
| CHEMBL3357195 | — | — | 1 | 5.28 |
| CHEMBL3357178 | — | — | 1 | 4.98 |
| CHEMBL3357181 | — | — | 1 | 4.92 |
| CHEMBL3357196 | — | — | 1 | 4.85 |
| CHEMBL3357179 | — | — | 1 | 4.80 |
| CHEMBL3357182 | — | — | 1 | 4.73 |
| CHEMBL3357200 | — | — | 1 | - |
| CHEMBL3357199 | — | — | 1 | - |
| CHEMBL3357198 | — | — | 1 | - |
| CHEMBL3357197 | — | — | 1 | - |
| CHEMBL3357175 | — | — | 1 | - |
| CHEMBL3357186 | — | — | 1 | - |
| CHEMBL3357185 | — | — | 1 | - |
| CHEMBL3357184 | — | — | 1 | - |
| CHEMBL3357183 | — | — | 1 | - |
| CHEMBL3357176 | — | — | 1 | - |
| CHEMBL3357180 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2012519 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3357191 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL3357190 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL3357193 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL3357188 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL3357192 | — | IC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL3357194 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3357177 | — | IC50 | = | 2810.0 | nM | 5.55 |
| CHEMBL3357189 | — | IC50 | = | 3030.0 | nM | 5.52 |
| CHEMBL3357187 | — | IC50 | = | 3610.0 | nM | 5.44 |
| CHEMBL3357195 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL3357178 | — | IC50 | = | 10520.0 | nM | 4.98 |
| CHEMBL3357181 | — | IC50 | = | 12030.0 | nM | 4.92 |
| CHEMBL3357196 | — | IC50 | = | 14150.0 | nM | 4.85 |
| CHEMBL3357179 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL3357182 | — | IC50 | = | 18590.0 | nM | 4.73 |
| CHEMBL3357200 | — | IC50 | >= | 30000.0 | nM | - |
| CHEMBL3357199 | — | IC50 | >= | 30000.0 | nM | - |
| CHEMBL3357198 | — | IC50 | >= | 30000.0 | nM | - |
| CHEMBL3357197 | — | IC50 | >= | 30000.0 | nM | - |
| CHEMBL3357175 | — | IC50 | >= | 30000.0 | nM | - |
| CHEMBL3357186 | — | IC50 | >= | 30000.0 | nM | - |
| CHEMBL3357185 | — | IC50 | >= | 30000.0 | nM | - |
| CHEMBL3357184 | — | IC50 | >= | 30000.0 | nM | - |
| CHEMBL3357183 | — | IC50 | >= | 30000.0 | nM | - |
| CHEMBL3357176 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3357180 | — | IC50 | > | 30000.0 | nM | - |