Assay Detail
Binding
CHEMBL3385490
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Inhibition of human recombinant ACC2 after 1 hr by transcreener assay
9
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Decreasing the rate of metabolic ketone reduction in the discovery of a clinical acetyl-CoA carboxylase inhibitor for the treatment of diabetes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.26 | 8.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2419601 | — | — | 1 | 8.01 |
| CHEMBL3359261 | — | — | 1 | 7.77 |
| CHEMBL3359264 | — | — | 1 | 7.64 |
| CHEMBL3359262 | — | — | 1 | 7.52 |
| CHEMBL3359265 | PF-05175157 | 2.0 | 1 | 7.35 |
| CHEMBL3359259 | — | — | 2 | 7.20 |
| CHEMBL3359263 | — | — | 1 | 6.79 |
| CHEMBL3359260 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2419601 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL3359261 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3359264 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3359262 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3359265 | PF-05175157 | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL3359259 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL3359259 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL3359263 | — | IC50 | = | 161.0 | nM | 6.79 |
| CHEMBL3359260 | — | IC50 | = | 1100.0 | nM | 5.96 |