Assay Detail
Binding
CHEMBL3385491
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG channel by patch-clamp assay
9
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Decreasing the rate of metabolic ketone reduction in the discovery of a clinical acetyl-CoA carboxylase inhibitor for the treatment of diabetes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.58 | 4.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3359261 | — | — | 1 | 4.68 |
| CHEMBL3359262 | — | — | 1 | 4.64 |
| CHEMBL3359264 | — | — | 1 | 4.54 |
| CHEMBL2419601 | — | — | 1 | 4.47 |
| CHEMBL3359265 | PF-05175157 | 2.0 | 1 | - |
| CHEMBL3359263 | — | — | 1 | - |
| CHEMBL3359260 | — | — | 1 | - |
| CHEMBL3359259 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3359261 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL3359262 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL3359264 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL2419601 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL3359265 | PF-05175157 | IC50 | = | 141000.0 | nM | - |
| CHEMBL3359263 | — | IC50 | - | — | - | |
| CHEMBL3359260 | — | IC50 | - | — | - | |
| CHEMBL3359259 | — | IC50 | - | — | - | |
| CHEMBL3359259 | — | IC50 | - | — | - |