Assay Detail
Functional
CHEMBL3385921
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anticoagulant activity in recombinant tissue factor and procoagulant phospholipids-stimulated human citrated plasma assessed as inhibition of thrombin peak by fluorometry based calibrated automated thrombography
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
How a β-D-glucoside side chain enhances binding affinity to thrombin of inhibitors bearing 2-chlorothiophene as P1 moiety: crystallography, fragment deconstruction study, and evaluation of antithrombotic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.79 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3343301 | — | — | 1 | 6.52 |
| CHEMBL3343300 | — | — | 1 | 5.92 |
| CHEMBL1166 | ARGATROBAN | 4.0 | 1 | 5.72 |
| CHEMBL3343299 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3343301 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3343300 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1166 | ARGATROBAN | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL3343299 | — | IC50 | = | 10000.0 | nM | 5.00 |