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Assay Detail

CHEMBL3386560

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Binding
Inhibition of Plasmodium falciparum IspC using 1-deoxy-D-xylulose 5-phosphate as substrate by photometric analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Plasmodium falciparum
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Binding modes of reverse fosmidomycin analogs toward the antimalarial target IspC.
Konzuch S, Umeda T, Held J, Hähn S, Brücher K, Lienau C, Behrendt CT, Gräwert T, Bacher A, Illarionov B, Fischer M, Mordmüller B, Tanaka N, Kurz T.
J Med Chem (2014) 57 : 8827 -8838
PubMed 25254502 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 6.73 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2164256 1 8.00
CHEMBL3341763 1 7.70
CHEMBL3342262 1 7.30
CHEMBL3342260 1 7.22
CHEMBL3342259 1 7.10
CHEMBL3342261 1 6.89
CHEMBL3342258 1 6.72
CHEMBL3342264 1 5.68
CHEMBL3342263 1 5.66
CHEMBL3342265 1 5.04
CHEMBL3342266 1 -
CHEMBL3342267 1 -
CHEMBL3342268 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2164256 IC50 = 10.0 nM 8.00
CHEMBL3341763 IC50 = 20.0 nM 7.70
CHEMBL3342262 IC50 = 50.0 nM 7.30
CHEMBL3342260 IC50 = 60.0 nM 7.22
CHEMBL3342259 IC50 = 80.0 nM 7.10
CHEMBL3342261 IC50 = 130.0 nM 6.89
CHEMBL3342258 IC50 = 190.0 nM 6.72
CHEMBL3342264 IC50 = 2100.0 nM 5.68
CHEMBL3342263 IC50 = 2200.0 nM 5.66
CHEMBL3342265 IC50 = 9100.0 nM 5.04
CHEMBL3342266 IC50 > 1000000.0 nM -
CHEMBL3342267 IC50 > 300000.0 nM -
CHEMBL3342268 IC50 > 300000.0 nM -