Assay Detail
Functional
CHEMBL3386591
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of oxidative phosphorylation in Mycobacterium smegmatis membrane vesicles assessed as inhibition of NADH driven ATP synthesis by luciferin/luciferase assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mycolicibacterium smegmatis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Mycolicibacterium smegmatis (CHEMBL613088) ↗| Type | ORGANISM |
| Organism | Mycolicibacterium smegmatis |
Publication
2-Phenylindole and Arylsulphonamide: Novel Scaffolds Bactericidal against Mycobacterium tuberculosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.91 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL376488 | BEDAQUILINE | 4.0 | 1 | 9.00 |
| CHEMBL3335464 | — | — | 1 | 4.81 |
| CHEMBL3335466 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL376488 | BEDAQUILINE | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3335464 | — | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL3335466 | — | IC50 | > | 70000.0 | nM | - |