Assay Detail
Binding
CHEMBL3386730
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Inhibition of Clostridium perfringens neuraminidase 4-methylumbelliferyl-alpha-D-Nacetylneuraminic acid sodium salt hydrate as substrate by fluorometry
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Clostridium perfringens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Neuraminidase inhibitory activities of quaternary isoquinoline alkaloids from Corydalis turtschaninovii rhizome.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.56 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 5.22 |
| CHEMBL206106 | PALMITINE | — | 1 | 4.89 |
| CHEMBL295124 | BERBERINE | 4.0 | 1 | 4.87 |
| CHEMBL362071 | COPTISINE | — | 1 | 4.60 |
| CHEMBL3343657 | — | — | 1 | 4.49 |
| CHEMBL251055 | JATRORRHIZINE | — | 1 | 4.43 |
| CHEMBL3343658 | — | — | 1 | 4.38 |
| CHEMBL3343659 | — | — | 1 | 4.19 |
| CHEMBL228082 | GLAUCINE | — | 1 | 4.01 |
| CHEMBL2165401 | — | — | 1 | - |
| CHEMBL3343660 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140 | CURCUMIN | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL206106 | PALMITINE | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL295124 | BERBERINE | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL362071 | COPTISINE | IC50 | = | 25100.0 | nM | 4.60 |
| CHEMBL3343657 | — | IC50 | = | 32600.0 | nM | 4.49 |
| CHEMBL251055 | JATRORRHIZINE | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL3343658 | — | IC50 | = | 41300.0 | nM | 4.38 |
| CHEMBL3343659 | — | IC50 | = | 65200.0 | nM | 4.19 |
| CHEMBL228082 | GLAUCINE | IC50 | = | 96900.0 | nM | 4.01 |
| CHEMBL2165401 | — | IC50 | - | — | - | |
| CHEMBL3343660 | — | IC50 | - | — | - |