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Assay Detail

CHEMBL3386732

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Binding
Inhibition of Influenza A virus H5N1 neuraminidase using 4-methylumbelliferyl-alpha-D-Nacetylneuraminic acid sodium salt hydrate as substrate by fluorometry
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Influenza A virus
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Neuraminidase (CHEMBL3559643)
Type SINGLE PROTEIN
Organism Influenza A virus (strain A/USSR/90/1977 H1N1)

Publication

Neuraminidase inhibitory activities of quaternary isoquinoline alkaloids from Corydalis turtschaninovii rhizome.
Kim JH, Ryu YB, Lee WS, Kim YH.
Bioorg Med Chem (2014) 22 : 6047 -6052
PubMed 25277281 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 4.42 5.09

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL140 CURCUMIN 3.0 1 5.09
CHEMBL362071 COPTISINE 1 4.58
CHEMBL206106 PALMITINE 1 4.53
CHEMBL295124 BERBERINE 4.0 1 4.49
CHEMBL251055 JATRORRHIZINE 1 4.12
CHEMBL3343657 1 4.08
CHEMBL1229 OSELTAMIVIR 4.0 1 4.05
CHEMBL3343658 1 -
CHEMBL3343659 1 -
CHEMBL228082 GLAUCINE 1 -
CHEMBL2165401 1 -
CHEMBL3343660 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL140 CURCUMIN IC50 = 8100.0 nM 5.09
CHEMBL362071 COPTISINE IC50 = 26400.0 nM 4.58
CHEMBL206106 PALMITINE IC50 = 29800.0 nM 4.53
CHEMBL295124 BERBERINE IC50 = 32200.0 nM 4.49
CHEMBL251055 JATRORRHIZINE IC50 = 76300.0 nM 4.12
CHEMBL3343657 IC50 = 83600.0 nM 4.08
CHEMBL1229 OSELTAMIVIR IC50 = 88200.0 nM 4.05
CHEMBL3343658 IC50 = 100200.0 nM -
CHEMBL3343659 IC50 = 167000.0 nM -
CHEMBL228082 GLAUCINE IC50 - -
CHEMBL2165401 IC50 - -
CHEMBL3343660 IC50 - -