Assay Detail
Binding
CHEMBL3386826
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Inhibition of rat CK1delta by radiometric protein kinase filter binding assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Difluoro-dioxolo-benzoimidazol-benzamides as potent inhibitors of CK1δ and ε with nanomolar inhibitory activity on cancer cell proliferation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.22 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3337849 | — | — | 1 | 7.75 |
| CHEMBL3337846 | — | — | 1 | 7.47 |
| CHEMBL3337855 | — | — | 1 | 6.97 |
| CHEMBL3337856 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3337849 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3337846 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL3337855 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL3337856 | — | IC50 | = | 201.0 | nM | 6.70 |