Assay Detail
Functional
CHEMBL3387033
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiparasitic activity against amastigote stage of Leishmania infantum infected in THP1 cells assessed as parasite growth inhibition after 24 hrs by hemocytometery
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania infantum |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of novel polysubstituted (2SR,4RS)-2-heteroaryltetrahydro-1,4-epoxy-1-benzazepines and cis-2-heteroaryl-4-hydroxytetrahydro-1H-1-benzazepines as antiparasitic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 50 | 6.10 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | 8.00 |
| CHEMBL3330184 | — | — | 1 | 4.19 |
| CHEMBL3330180 | — | — | 1 | - |
| CHEMBL3330179 | — | — | 1 | - |
| CHEMBL3330178 | — | — | 1 | - |
| CHEMBL3330190 | — | — | 1 | - |
| CHEMBL3330224 | — | — | 1 | - |
| CHEMBL3330223 | — | — | 1 | - |
| CHEMBL3330222 | — | — | 1 | - |
| CHEMBL3330221 | — | — | 1 | - |
| CHEMBL3330220 | — | — | 1 | - |
| CHEMBL3330219 | — | — | 1 | - |
| CHEMBL3330218 | — | — | 1 | - |
| CHEMBL3330217 | — | — | 1 | - |
| CHEMBL3330216 | — | — | 1 | - |
| CHEMBL3330215 | — | — | 1 | - |
| CHEMBL3330214 | — | — | 1 | - |
| CHEMBL3330213 | — | — | 1 | - |
| CHEMBL3330212 | — | — | 1 | - |
| CHEMBL3330211 | — | — | 1 | - |
| CHEMBL3330210 | — | — | 1 | - |
| CHEMBL3330209 | — | — | 1 | - |
| CHEMBL3330208 | — | — | 1 | - |
| CHEMBL3330207 | — | — | 1 | - |
| CHEMBL3329230 | — | — | 1 | - |
| CHEMBL3330206 | — | — | 1 | - |
| CHEMBL3330205 | — | — | 1 | - |
| CHEMBL3330204 | — | — | 1 | - |
| CHEMBL3330202 | — | — | 1 | - |
| CHEMBL3330203 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3330184 | — | IC50 | = | 65200.0 | nM | 4.19 |
| CHEMBL3330190 | — | IC50 | > | 293200.0 | nM | - |
| CHEMBL3330201 | — | IC50 | > | 307600.0 | nM | - |
| CHEMBL3330178 | — | IC50 | > | 389000.0 | nM | - |
| CHEMBL3330179 | — | IC50 | = | 368100.0 | nM | - |
| CHEMBL3330180 | — | IC50 | > | 311500.0 | nM | - |
| CHEMBL3330181 | — | IC50 | > | 120200.0 | nM | - |
| CHEMBL3330182 | — | IC50 | > | 343600.0 | nM | - |
| CHEMBL3330183 | — | IC50 | > | 343600.0 | nM | - |
| CHEMBL3330185 | — | IC50 | = | 177200.0 | nM | - |
| CHEMBL3330186 | — | IC50 | > | 121100.0 | nM | - |
| CHEMBL3330187 | — | IC50 | = | 203600.0 | nM | - |
| CHEMBL3330188 | — | IC50 | > | 295000.0 | nM | - |
| CHEMBL3330189 | — | IC50 | > | 305800.0 | nM | - |
| CHEMBL3330177 | — | IC50 | = | 405800.0 | nM | - |
| CHEMBL3330191 | — | IC50 | > | 293200.0 | nM | - |
| CHEMBL3330192 | — | IC50 | > | 440400.0 | nM | - |
| CHEMBL3330193 | — | IC50 | = | 398400.0 | nM | - |
| CHEMBL3330194 | — | IC50 | > | 367600.0 | nM | - |
| CHEMBL3330195 | — | IC50 | > | 127600.0 | nM | - |
| CHEMBL3330196 | — | IC50 | > | 129500.0 | nM | - |
| CHEMBL3330197 | — | IC50 | > | 135900.0 | nM | - |
| CHEMBL3330198 | — | IC50 | > | 128500.0 | nM | - |
| CHEMBL3330199 | — | IC50 | > | 114800.0 | nM | - |
| CHEMBL3330200 | — | IC50 | = | 171800.0 | nM | - |
| CHEMBL3330212 | — | IC50 | > | 120200.0 | nM | - |
| CHEMBL3330203 | — | IC50 | > | 408000.0 | nM | - |
| CHEMBL3330202 | — | IC50 | > | 280900.0 | nM | - |
| CHEMBL3330204 | — | IC50 | > | 321500.0 | nM | - |
| CHEMBL3330205 | — | IC50 | > | 387400.0 | nM | - |
| CHEMBL3330206 | — | IC50 | = | 138000.0 | nM | - |
| CHEMBL3329230 | — | IC50 | > | 128500.0 | nM | - |
| CHEMBL3330207 | — | IC50 | > | 128500.0 | nM | - |
| CHEMBL3330208 | — | IC50 | > | 119300.0 | nM | - |
| CHEMBL3330209 | — | IC50 | > | 341200.0 | nM | - |
| CHEMBL3330210 | — | IC50 | > | 341200.0 | nM | - |
| CHEMBL3330211 | — | IC50 | > | 380100.0 | nM | - |
| CHEMBL3330224 | — | IC50 | > | 106400.0 | nM | - |
| CHEMBL3330213 | — | IC50 | > | 120200.0 | nM | - |
| CHEMBL3330214 | — | IC50 | > | 101200.0 | nM | - |
| CHEMBL3330215 | — | IC50 | - | — | - | |
| CHEMBL3330216 | — | IC50 | > | 97100.0 | nM | - |
| CHEMBL3330217 | — | IC50 | > | 436500.0 | nM | - |
| CHEMBL3330218 | — | IC50 | > | 411300.0 | nM | - |
| CHEMBL3330219 | — | IC50 | > | 360900.0 | nM | - |
| CHEMBL3330220 | — | IC50 | > | 383000.0 | nM | - |
| CHEMBL3330221 | — | IC50 | > | 106400.0 | nM | - |
| CHEMBL3330222 | — | IC50 | > | 101800.0 | nM | - |
| CHEMBL3330223 | — | IC50 | > | 404700.0 | nM | - |