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Assay Detail

CHEMBL3387073

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydrase assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Carbonic anhydrase 2 (CHEMBL205)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Carbonic anhydrase inhibitory activity of sulfonamides and carboxylic acids incorporating cyclic imide scaffolds.
Abdel-Aziz AA, El-Azab AS, Ceruso M, Supuran CT.
Bioorg Med Chem Lett (2014) 24 : 5185 -5189
PubMed 25442309 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 29 7.86 8.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL520850 1 8.66
CHEMBL2377786 1 8.64
CHEMBL2377773 1 8.37
CHEMBL2377784 1 8.32
CHEMBL2377794 1 8.29
CHEMBL2377778 1 8.28
CHEMBL2377791 1 8.25
CHEMBL2377790 1 8.21
CHEMBL2377788 1 8.11
CHEMBL2377776 1 8.07
CHEMBL2377783 1 8.04
CHEMBL2377781 1 8.00
CHEMBL2377793 1 7.95
CHEMBL20 ACETAZOLAMIDE 4.0 1 7.92
CHEMBL2377787 1 7.58
CHEMBL2377780 1 7.56
CHEMBL2377775 1 7.33
CHEMBL2377779 1 7.31
CHEMBL312097 1 6.78
CHEMBL2377785 1 6.72
CHEMBL2377772 1 6.62
CHEMBL2377792 1 -
CHEMBL2377789 1 -
CHEMBL2377795 1 -
CHEMBL2377771 1 -
CHEMBL2377774 1 -
CHEMBL2377777 1 -
CHEMBL2377782 1 -
CHEMBL1501298 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL520850 Ki = 2.2 nM 8.66
CHEMBL2377786 Ki = 2.3 nM 8.64
CHEMBL2377773 Ki = 4.3 nM 8.37
CHEMBL2377784 Ki = 4.8 nM 8.32
CHEMBL2377794 Ki = 5.1 nM 8.29
CHEMBL2377778 Ki = 5.3 nM 8.28
CHEMBL2377791 Ki = 5.6 nM 8.25
CHEMBL2377790 Ki = 6.2 nM 8.21
CHEMBL2377788 Ki = 7.8 nM 8.11
CHEMBL2377776 Ki = 8.6 nM 8.07
CHEMBL2377783 Ki = 9.1 nM 8.04
CHEMBL2377781 Ki = 10.1 nM 8.00
CHEMBL2377793 Ki = 11.3 nM 7.95
CHEMBL20 ACETAZOLAMIDE Ki = 12.0 nM 7.92
CHEMBL2377787 Ki = 26.2 nM 7.58
CHEMBL2377780 Ki = 27.6 nM 7.56
CHEMBL2377775 Ki = 47.2 nM 7.33
CHEMBL2377779 Ki = 49.0 nM 7.31
CHEMBL312097 Ki = 166.0 nM 6.78
CHEMBL2377785 Ki = 190.0 nM 6.72
CHEMBL2377772 Ki = 238.0 nM 6.62
CHEMBL2377792 Ki > 1000.0 nM -
CHEMBL2377789 Ki > 1000.0 nM -
CHEMBL2377795 Ki > 1000.0 nM -
CHEMBL2377771 Ki > 1000.0 nM -
CHEMBL2377774 Ki > 1000.0 nM -
CHEMBL2377777 Ki > 1000.0 nM -
CHEMBL2377782 Ki > 1000.0 nM -
CHEMBL1501298 Ki > 1000.0 nM -