Assay Detail
Binding
CHEMBL3387075
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Inhibition of human carbonic anhydrase 12 by stopped-flow CO2 hydrase assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Carbonic anhydrase inhibitory activity of sulfonamides and carboxylic acids incorporating cyclic imide scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 31 | 8.68 | 9.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL520850 | — | — | 1 | 9.28 |
| CHEMBL2377786 | — | — | 1 | 9.26 |
| CHEMBL2377784 | — | — | 1 | 9.24 |
| CHEMBL2377783 | — | — | 1 | 9.22 |
| CHEMBL2377770 | — | — | 1 | 9.22 |
| CHEMBL2377781 | — | — | 1 | 9.20 |
| CHEMBL2377782 | — | — | 1 | 9.18 |
| CHEMBL2377785 | — | — | 1 | 9.18 |
| CHEMBL2377780 | — | — | 1 | 9.17 |
| CHEMBL2377796 | — | — | 1 | 9.16 |
| CHEMBL2377793 | — | — | 1 | 9.11 |
| CHEMBL2377794 | — | — | 1 | 9.11 |
| CHEMBL2377787 | — | — | 1 | 9.07 |
| CHEMBL2377792 | — | — | 1 | 9.05 |
| CHEMBL2377776 | — | — | 1 | 9.03 |
| CHEMBL2377774 | — | — | 1 | 9.01 |
| CHEMBL2377779 | — | — | 1 | 9.00 |
| CHEMBL2377777 | — | — | 1 | 9.00 |
| CHEMBL2377775 | — | — | 1 | 9.00 |
| CHEMBL2377778 | — | — | 1 | 8.96 |
| CHEMBL1501298 | — | — | 1 | 8.92 |
| CHEMBL2377791 | — | — | 1 | 8.57 |
| CHEMBL2377790 | — | — | 1 | 8.51 |
| CHEMBL2377788 | — | — | 1 | 8.39 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.24 |
| CHEMBL312097 | — | — | 1 | 7.73 |
| CHEMBL2377771 | — | — | 1 | 7.58 |
| CHEMBL2377795 | — | — | 1 | 7.52 |
| CHEMBL2377789 | — | — | 1 | 7.09 |
| CHEMBL2377773 | — | — | 1 | 7.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL520850 | — | Ki | = | 0.53 | nM | 9.28 |
| CHEMBL2377786 | — | Ki | = | 0.55 | nM | 9.26 |
| CHEMBL2377784 | — | Ki | = | 0.57 | nM | 9.24 |
| CHEMBL2377783 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL2377770 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL2377781 | — | Ki | = | 0.63 | nM | 9.20 |
| CHEMBL2377782 | — | Ki | = | 0.66 | nM | 9.18 |
| CHEMBL2377785 | — | Ki | = | 0.66 | nM | 9.18 |
| CHEMBL2377780 | — | Ki | = | 0.68 | nM | 9.17 |
| CHEMBL2377796 | — | Ki | = | 0.69 | nM | 9.16 |
| CHEMBL2377793 | — | Ki | = | 0.77 | nM | 9.11 |
| CHEMBL2377794 | — | Ki | = | 0.78 | nM | 9.11 |
| CHEMBL2377787 | — | Ki | = | 0.85 | nM | 9.07 |
| CHEMBL2377792 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL2377776 | — | Ki | = | 0.93 | nM | 9.03 |
| CHEMBL2377774 | — | Ki | = | 0.98 | nM | 9.01 |
| CHEMBL2377779 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL2377777 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL2377775 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL2377778 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL1501298 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL2377791 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL2377790 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL2377788 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL312097 | — | Ki | = | 18.7 | nM | 7.73 |
| CHEMBL2377771 | — | Ki | = | 26.1 | nM | 7.58 |
| CHEMBL2377795 | — | Ki | = | 30.2 | nM | 7.52 |
| CHEMBL2377789 | — | Ki | = | 80.3 | nM | 7.09 |
| CHEMBL2377773 | — | Ki | = | 90.5 | nM | 7.04 |
| CHEMBL2377772 | — | Ki | = | 119.0 | nM | 6.92 |