Assay Detail
Binding
CHEMBL3387083
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Non-competitive inhibition of full-length recombinant human MMP-13 assessed as fTHP-15 substrate hydrolysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Characterization of selective exosite-binding inhibitors of matrix metalloproteinase 13 that prevent articular cartilage degradation in vitro.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.29 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL496942 | — | — | 1 | 7.85 |
| CHEMBL514794 | — | — | 1 | 6.96 |
| CHEMBL1371684 | — | — | 1 | 5.62 |
| CHEMBL1515648 | — | — | 1 | 5.55 |
| CHEMBL473326 | — | — | 1 | 5.47 |
| CHEMBL734 | ACETOHYDROXAMIC ACID | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL496942 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL514794 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1371684 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL1515648 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL473326 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL734 | ACETOHYDROXAMIC ACID | IC50 | - | — | - |