Assay Detail
Binding
CHEMBL3387086
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Inhibition of full-length recombinant human MMP-13 assessed as bovine type-2 collagen hydrolysis after 18 hrs by ELISA
8
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Characterization of selective exosite-binding inhibitors of matrix metalloproteinase 13 that prevent articular cartilage degradation in vitro.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 4 | - | - |
| IC50 | 4 | 6.34 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL514794 | — | — | 2 | 7.16 |
| CHEMBL1371684 | — | — | 2 | 6.40 |
| CHEMBL473326 | — | — | 2 | 6.16 |
| CHEMBL1515648 | — | — | 2 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL514794 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1371684 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL473326 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL1515648 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1515648 | — | Inhibition | - | % | - | |
| CHEMBL473326 | — | Inhibition | - | % | - | |
| CHEMBL514794 | — | Inhibition | - | % | - | |
| CHEMBL1371684 | — | Inhibition | - | % | - |