Assay Detail
Binding
CHEMBL3387343
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Binding affinity to GluA2-LBD-L483Y-N754S complex (unknown origin) by isothermal titration calorimetry
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Positive allosteric modulators of 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors belonging to 4-cyclopropyl-3,4-dihydro-2h-1,2,4-pyridothiadiazine dioxides and diversely chloro-substituted 4-cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 5.57 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2441067 | — | — | 1 | 6.46 |
| CHEMBL411612 | — | — | 1 | 5.25 |
| CHEMBL103741 | — | — | 1 | 5.01 |
| CHEMBL99732 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2441067 | — | Kd | = | 350.0 | nM | 6.46 |
| CHEMBL411612 | — | Kd | = | 5600.0 | nM | 5.25 |
| CHEMBL103741 | — | Kd | = | 9800.0 | nM | 5.01 |
| CHEMBL99732 | — | Kd | = | 1200000.0 | nM | - |