Assay Detail
Binding
CHEMBL3387346
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Positive allosteric modulation of AMPA receptor in rat embryonic cortex primary neuronal culture assessed as increase in AMPA-induced membrane depolarization by microplate reader
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | Primary neuron |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Positive allosteric modulators of 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors belonging to 4-cyclopropyl-3,4-dihydro-2h-1,2,4-pyridothiadiazine dioxides and diversely chloro-substituted 4-cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 5.80 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2441067 | — | — | 1 | 6.05 |
| CHEMBL3352932 | — | — | 1 | 5.82 |
| CHEMBL2441068 | — | — | 1 | 5.54 |
| CHEMBL3352936 | — | — | 1 | - |
| CHEMBL3352935 | — | — | 1 | - |
| CHEMBL3352934 | — | — | 1 | - |
| CHEMBL3352933 | — | — | 1 | - |
| CHEMBL3352931 | — | — | 1 | - |
| CHEMBL3352930 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2441067 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3352932 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2441068 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL3352936 | — | EC50 | - | — | - | |
| CHEMBL3352935 | — | EC50 | - | — | - | |
| CHEMBL3352934 | — | EC50 | - | — | - | |
| CHEMBL3352933 | — | EC50 | - | — | - | |
| CHEMBL3352931 | — | EC50 | - | — | - | |
| CHEMBL3352930 | — | EC50 | - | — | - |