Assay Detail
Binding
CHEMBL3387730
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Inhibition of Staphylococcus aureus FabI assessed as oxidation of NADH to NAD+ by spectrophotometrically
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis, molecular docking and biological evaluation of coumarin derivatives containing piperazine skeleton as potential antibacterial agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 4.92 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3344338 | — | — | 1 | 6.24 |
| CHEMBL3344351 | — | — | 1 | 6.08 |
| CHEMBL3344345 | — | — | 1 | 6.01 |
| CHEMBL3344355 | — | — | 1 | 5.74 |
| CHEMBL3341784 | — | — | 1 | 5.56 |
| CHEMBL3344336 | — | — | 1 | 5.42 |
| CHEMBL3344350 | — | — | 1 | 5.33 |
| CHEMBL3344337 | — | — | 1 | 5.26 |
| CHEMBL3344335 | — | — | 1 | 5.21 |
| CHEMBL3344349 | — | — | 1 | 5.15 |
| CHEMBL3344352 | — | — | 1 | 5.08 |
| CHEMBL3344348 | — | — | 1 | 4.94 |
| CHEMBL3344339 | — | — | 1 | 4.90 |
| CHEMBL3344341 | — | — | 1 | 4.75 |
| CHEMBL2393498 | — | — | 1 | 4.70 |
| CHEMBL3344353 | — | — | 1 | 4.66 |
| CHEMBL3344340 | — | — | 1 | 4.65 |
| CHEMBL3344354 | — | — | 1 | 4.58 |
| CHEMBL3344342 | — | — | 1 | 4.50 |
| CHEMBL3344346 | — | — | 1 | 4.45 |
| CHEMBL2393500 | — | — | 1 | 4.42 |
| CHEMBL3344334 | — | — | 1 | 4.38 |
| CHEMBL3344347 | — | — | 1 | 4.37 |
| CHEMBL2393499 | — | — | 1 | 4.36 |
| CHEMBL2393497 | — | — | 1 | 4.34 |
| CHEMBL3344333 | — | — | 1 | 4.32 |
| CHEMBL3344344 | — | — | 1 | 4.20 |
| CHEMBL3344343 | — | — | 1 | 4.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3344338 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL3344351 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL3344345 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL3344355 | — | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL3341784 | — | IC50 | = | 2730.0 | nM | 5.56 |
| CHEMBL3344336 | — | IC50 | = | 3820.0 | nM | 5.42 |
| CHEMBL3344350 | — | IC50 | = | 4620.0 | nM | 5.33 |
| CHEMBL3344337 | — | IC50 | = | 5540.0 | nM | 5.26 |
| CHEMBL3344335 | — | IC50 | = | 6230.0 | nM | 5.21 |
| CHEMBL3344349 | — | IC50 | = | 7150.0 | nM | 5.15 |
| CHEMBL3344352 | — | IC50 | = | 8410.0 | nM | 5.08 |
| CHEMBL3344348 | — | IC50 | = | 11370.0 | nM | 4.94 |
| CHEMBL3344339 | — | IC50 | = | 12510.0 | nM | 4.90 |
| CHEMBL3344341 | — | IC50 | = | 17660.0 | nM | 4.75 |
| CHEMBL2393498 | — | IC50 | = | 19750.0 | nM | 4.70 |
| CHEMBL3344353 | — | IC50 | = | 21940.0 | nM | 4.66 |
| CHEMBL3344340 | — | IC50 | = | 22270.0 | nM | 4.65 |
| CHEMBL3344354 | — | IC50 | = | 26570.0 | nM | 4.58 |
| CHEMBL3344342 | — | IC50 | = | 31390.0 | nM | 4.50 |
| CHEMBL3344346 | — | IC50 | = | 35490.0 | nM | 4.45 |
| CHEMBL2393500 | — | IC50 | = | 37570.0 | nM | 4.42 |
| CHEMBL3344334 | — | IC50 | = | 41260.0 | nM | 4.38 |
| CHEMBL3344347 | — | IC50 | = | 42520.0 | nM | 4.37 |
| CHEMBL2393499 | — | IC50 | = | 43220.0 | nM | 4.36 |
| CHEMBL2393497 | — | IC50 | = | 45510.0 | nM | 4.34 |
| CHEMBL3344333 | — | IC50 | = | 47790.0 | nM | 4.32 |
| CHEMBL3344344 | — | IC50 | = | 62850.0 | nM | 4.20 |
| CHEMBL3344343 | — | IC50 | = | 71090.0 | nM | 4.15 |