Assay Detail
Binding
CHEMBL3387776
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Inhibition of IFNgamma-induced STAT1 phosphorylation in human Cal33 cells by Western blot analysis
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CAL-33 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Signal transducer and activator of transcription 1-alpha/beta (CHEMBL6101) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
2-Guanidinoquinazolines as new inhibitors of the STAT3 pathway.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 4.66 | 5.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL522887 | — | — | 1 | 5.23 |
| CHEMBL1603850 | — | — | 1 | 4.92 |
| CHEMBL3337621 | — | — | 1 | 4.45 |
| CHEMBL3337620 | — | — | 1 | 4.40 |
| CHEMBL3337619 | — | — | 1 | 4.30 |
| CHEMBL1319541 | — | — | 1 | - |
| CHEMBL3337604 | — | — | 1 | - |
| CHEMBL3337612 | — | — | 1 | - |
| CHEMBL1652424 | — | — | 1 | - |
| CHEMBL3337611 | — | — | 1 | - |
| CHEMBL3337610 | — | — | 1 | - |
| CHEMBL3337609 | — | — | 1 | - |
| CHEMBL3337457 | — | — | 1 | - |
| CHEMBL3337608 | — | — | 1 | - |
| CHEMBL3337607 | — | — | 1 | - |
| CHEMBL3337606 | — | — | 1 | - |
| CHEMBL3337605 | — | — | 1 | - |
| CHEMBL3337614 | — | — | 1 | - |
| CHEMBL1439622 | — | — | 1 | - |
| CHEMBL3337627 | — | — | 1 | - |
| CHEMBL3337626 | — | — | 1 | - |
| CHEMBL3337625 | — | — | 1 | - |
| CHEMBL3337624 | — | — | 1 | - |
| CHEMBL3337623 | — | — | 1 | - |
| CHEMBL3337613 | — | — | 1 | - |
| CHEMBL3337618 | — | — | 1 | - |
| CHEMBL3337617 | — | — | 1 | - |
| CHEMBL3337616 | — | — | 1 | - |
| CHEMBL3337615 | — | — | 1 | - |
| CHEMBL3337622 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL522887 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL1603850 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL3337621 | — | IC50 | = | 35200.0 | nM | 4.45 |
| CHEMBL3337620 | — | IC50 | = | 39700.0 | nM | 4.40 |
| CHEMBL3337619 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL3337612 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3337603 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1652424 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3337611 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3337610 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3337609 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3337457 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3337608 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3337607 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3337606 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3337605 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3337604 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1528359 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1319541 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3337614 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1439622 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3337627 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3337626 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3337625 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3337624 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3337623 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3337613 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3337618 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3337617 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3337616 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3337615 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3337622 | — | IC50 | > | 50000.0 | nM | - |