Assay Detail
Binding
CHEMBL3387952
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Inhibition of Enterobacter cloacae KPC-2 pre-incubated with enzyme for 5 mins before nitrocefin substrate addition by colorimetric assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Enterobacter cloacae |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Enantioselective Synthesis and Profiling of Two Novel Diazabicyclooctanone β-Lactamase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.22 | 6.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3342555 | — | — | 1 | 6.07 |
| CHEMBL3341766 | — | — | 1 | 5.17 |
| CHEMBL404 | TAZOBACTAM | 4.0 | 1 | 4.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3342555 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL3341766 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL404 | TAZOBACTAM | IC50 | = | 39000.0 | nM | 4.41 |