Assay Detail
Binding
CHEMBL3388144
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Inhibition of human recombinant JAK2
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Triazolopyridines as selective JAK1 inhibitors: from hit identification to GLPG0634.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.59 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1789941 | RUXOLITINIB | 4.0 | 1 | 9.70 |
| CHEMBL221959 | TOFACITINIB | 4.0 | 1 | 9.22 |
| CHEMBL3360318 | — | — | 1 | 6.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1789941 | RUXOLITINIB | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL221959 | TOFACITINIB | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL3360318 | — | IC50 | = | 138.0 | nM | 6.86 |