Assay Detail
Binding
CHEMBL3388367
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Inhibition of chymotrypsin-like activity of proteasome in HEK293 cells incubated for 1 hr by proteasome Glo cell-based chemiluminescent assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 2 — Organism |
| Curated By | Autocuration |
Publication
Noncovalent fluorescent probes of human immuno- and constitutive proteasomes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.88 | 7.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3357584 | — | — | 1 | 7.19 |
| CHEMBL3357585 | — | — | 1 | 6.90 |
| CHEMBL3357583 | — | — | 1 | 6.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3357584 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL3357585 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL3357583 | — | IC50 | = | 289.0 | nM | 6.54 |